As health centers integrate PrEP for HIV prevention into their primary care services, it is important to align with the latest guidance and research. The PrEP checklist from UNC School of Medicine's North Carolina HIV Training & Education Center offers step-by-step detailed guidance for providing PrEP. This checklist can be used to inform workflow, EHR, and other health IT updates including order sets and clinical decision support. It can also be used as a reference for providers who are newer to providing PrEP who are prompted or alerted to a patient's potential need for HIV prevention services.